{"product_id":"berberine","title":"Berberine","description":"\u003cp\u003eThe metabolic compound that matched metformin in head-to-head trials.\u003c\/p\u003e\u003ch2\u003eThe science\u003c\/h2\u003e\u003cp\u003eBerberine activates AMPK — the enzyme that regulates how cells produce and use energy. In a 2012 meta-analysis of 14 RCTs, berberine reduced HbA1c, fasting glucose, and post-meal glucose at levels comparable to metformin. Separate trials show consistent reductions in LDL cholesterol and triglycerides. The mechanisms are well characterised, and 500mg HCl is the dose used across virtually all the clinical literature.\u003c\/p\u003e\u003ch2\u003eHow to take it\u003c\/h2\u003e\u003cp\u003e500mg (1 capsule) up to 3 times daily with meals. Start with one capsule daily and increase over 2 weeks — this allows your gut microbiome to adjust and minimises the GI sensitivity some people experience at higher doses.\u003c\/p\u003e\u003ch2\u003eWhat’s inside\u003c\/h2\u003e\u003cp\u003eEvery batch independently tested. Scan the QR code on your label to view the Certificate of Analysis for your exact batch.\u003cbr\u003eServing size: 1 capsule | 60 servings | Berberine HCl: 500mg\u003cbr\u003eGluten-free. Non-GMO. Vegetarian.\u003c\/p\u003e\u003ch2\u003eCommon questions\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eHow does berberine compare to metformin?\u003c\/strong\u003e\u003cbr\u003eA 2012 meta-analysis found berberine and metformin produced nearly identical reductions in HbA1c and fasting glucose across head-to-head trials. Berberine also improved lipid profiles in ways metformin doesn’t. It’s not a pharmaceutical — it doesn’t require a prescription and operates through the same AMPK pathway without metformin’s GI side effects for most people.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhen is the best time to take berberine?\u003c\/strong\u003e\u003cbr\u003eWith meals. Berberine’s glucose-regulating effect is most relevant in the context of food intake — taking it 15–30 minutes before meals produces the best glycaemic response.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDoes berberine cause stomach problems?\u003c\/strong\u003e\u003cbr\u003eSome people experience mild GI symptoms at higher doses. Starting with a single 500mg capsule daily and increasing gradually over two weeks reduces this significantly. The effect typically resolves once your gut adapts.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCan I take berberine with medications?\u003c\/strong\u003e\u003cbr\u003eBerberine is metabolised by cytochrome P450 enzymes and may interact with drugs that use the same pathway — particularly statins, metformin, and blood pressure medications. If you’re on prescription medication, consult your doctor before adding berberine.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDoes berberine affect the gut microbiome?\u003c\/strong\u003e\u003cbr\u003eYes. Berberine has demonstrated antimicrobial properties and alters gut flora composition. This is one reason to cycle berberine rather than take it indefinitely without breaks.\u003c\/p\u003e","brand":"Proco","offers":[{"title":"Default Title","offer_id":58008216469768,"sku":"JTP4BERB","price":40.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1047\/0585\/1656\/files\/1781360574034-generated-label-image-0.jpg?v=1781429890","url":"https:\/\/shop.procohq.com\/products\/berberine","provider":"Proco","version":"1.0","type":"link"}