Berberine

The metabolic compound that matched metformin in head-to-head trials.

The science

Berberine activates AMPK — the enzyme that regulates how cells produce and use energy. In a 2012 meta-analysis of 14 RCTs, berberine reduced HbA1c, fasting glucose, and post-meal glucose at levels comparable to metformin. Separate trials show consistent reductions in LDL cholesterol and triglycerides. The mechanisms are well characterised, and 500mg HCl is the dose used across virtually all the clinical literature.

How to take it

500mg (1 capsule) up to 3 times daily with meals. Start with one capsule daily and increase over 2 weeks — this allows your gut microbiome to adjust and minimises the GI sensitivity some people experience at higher doses.

What’s inside

Every batch independently tested. Scan the QR code on your label to view the Certificate of Analysis for your exact batch.
Serving size: 1 capsule | 60 servings | Berberine HCl: 500mg
Gluten-free. Non-GMO. Vegetarian.

Common questions

How does berberine compare to metformin?
A 2012 meta-analysis found berberine and metformin produced nearly identical reductions in HbA1c and fasting glucose across head-to-head trials. Berberine also improved lipid profiles in ways metformin doesn’t. It’s not a pharmaceutical — it doesn’t require a prescription and operates through the same AMPK pathway without metformin’s GI side effects for most people.

When is the best time to take berberine?
With meals. Berberine’s glucose-regulating effect is most relevant in the context of food intake — taking it 15–30 minutes before meals produces the best glycaemic response.

Does berberine cause stomach problems?
Some people experience mild GI symptoms at higher doses. Starting with a single 500mg capsule daily and increasing gradually over two weeks reduces this significantly. The effect typically resolves once your gut adapts.

Can I take berberine with medications?
Berberine is metabolised by cytochrome P450 enzymes and may interact with drugs that use the same pathway — particularly statins, metformin, and blood pressure medications. If you’re on prescription medication, consult your doctor before adding berberine.

Does berberine affect the gut microbiome?
Yes. Berberine has demonstrated antimicrobial properties and alters gut flora composition. This is one reason to cycle berberine rather than take it indefinitely without breaks.